PLSMC is a novel algorithm based on a penalized least square method to detect complex in PPI network. PLSMC is to minimize the distances between the interaction and co-complex of protein pairs.
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A least square method based model for identifying protein complexes in protein-protein interaction network.
Dai Q, Guo M, Guo Y, Liu X, Liu Y, Teng Z.
Biomed Res Int. 2014;2014:720960. doi: 10.1155/2014/720960.