PhyME
:: DESCRIPTION
PhyME (Phylogenetic Motif Elicitation) is a software tool for finding motifs in sets of orthologous sequences.PhyME is an ab initio motif-finding algorithm, which finds overrepresented motifs in input sequences while accounting for their evolutionary conservation in orthologs of those sequences.
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PhyME discovers motifs by integrating two important aspects of the motif’s significance, overrepresentation and interspecies conservation, into one probabilistic score. The algorithm is based on multiple alignment and expectation-maximization.
::DEVELOPER
:: SCREENSHOTS
N/A
:: REQUIREMENTS
- Linux
- GCC
:: DOWNLOAD
:: MORE INFORMATION
- S. Sinha, “PhyME: a software tool for finding motifs in sets of orthologous sequences”, Methods Mol. Biol., vol. 395 (2007) 309-18. Pubmed 17993682.
- S. Sinha, M. Blanchette, M. Tompa, “PhyME: a probabilistic algorithm for finding motifs in sets of orthologous sequences”, BMC Bioinformatics, vol. 5(2004) 170. Pubmed 15511292.