normGAM is an R package for normalizing genome architecture mapping (GAM) data. It implements five normalization methods, including normalized linkage disequilibrium (NLD), vanilla coverage (VC), sequential component normalization (SCN), iterative correction and eigenvector decomposition (ICE), and Knight-Ruiz 2-norm (KR2). The normalization procedure can remove known and unknown systematic biases, the known biases including window detection frequency, fragment length, mappability, and GC content.
- Linux / Windows
:: MORE INFORMATION
Liu T, Wang Z.
normGAM: an R package to remove systematic biases in genome architecture mapping data.
BMC Genomics. 2019 Dec 30;20(Suppl 12):1006. doi: 10.1186/s12864-019-6331-8. PMID: 31888469; PMCID: PMC6936146.