miReduce correlates the logarithm of expression fold changes of a set of genes with the motif content of the regulatory sequences of these genes. In particular, it correlates the genome wide mRNA log fold changes in experiments involving the knockout/knockdown/overexpression of one or more miRNAs with the motif content of the 3’UTRs. The model is based on linear regression, and is intended for genome-wide studies.
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Pranidhi Sood, Azra Krek, Mihaela Zavolan, Giuseppe Macino, and Nikolaus Rajewsky
“Cell-type-specific signatures of microRNAs on target mRNA expression“,
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2746-51. Epub 2006 Feb 13.