GRaPe (Gene Reaction Protein Builder) was developed to enable the generation of generic rate equations for all reactions in a model. It encompasses an algorithm for estimating the concentration of proteins for a reaction to reach a particular steady state when kinetic parameters are unknown, and two robust methods for parameter estimation. It also allows for the seamless integration of gene expression or protein levels into a reaction and can generate equations for both transcription and translation.
Pathways and biological systems modelling group , The University of Manchester
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Adiamah DA, Handl J, Schwartz JM (2010).
Streamlining the construction of large-scale dynamic models using generic kinetic equations.
Bioinformatics 26: 1324-31.