GGDC is an updated and enhanced version with improved DDH-prediction models and additional features such as confidence-interval estimation. To the best of our knowledge, it is the only digital DDH method that provides this feature. Of all genome-based methods we are aware of, GGDC 2.0 yields the highest correspondence to wet-lab DDH (without sharing DDH’s drawbacks).
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BMC Bioinformatics. 2013 Feb 21;14:60. doi: 10.1186/1471-2105-14-60.
Genome sequence-based species delimitation with confidence intervals and improved distance functions.
Meier-Kolthoff JP1, Auch AF, Klenk HP, Göker M.