gfold (Generalized fold change) generalizes the fold change by considering the posterior distribution of log fold change, such that each gene is assigned a reliable fold change. It overcomes the shortcoming of p-value that measures the significance of whether a gene is differentially expressed under different conditions instead of measuring relative expression changes, which are more interesting in many studies. It also overcomes the shortcoming of fold change that suffers from the fact that the fold change of genes with low read count are not so reliable as that of genes with high read count, even these two genes show the same fold change.
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Feng J, Meyer CA, Wang Q, Liu JS, Liu XS, Zhang Y.
GFOLD: a generalized fold change for ranking differentially ex-pressed genes from RNA-seq data.
Bioinformatics (2012) 28 (21): 2782-2788.