GESTALT is a method that uses genome editing to progressively introduce and accumulate diverse mutations in a DNA barcode over multiple rounds of cell division, thereby recording cell lineage relationships in the patterns of mutations shared between cells.
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McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J.
Whole-organism lineage tracing by combinatorial and cumulative genome editing.
Science. 2016 Jul 29;353(6298):aaf7907. doi: 10.1126/science.aaf7907. Epub 2016 May 26. PMID: 27229144; PMCID: PMC4967023.