FABIAN

:: DESCRIPTION

FABIAN supports more than 1,000 different binding models for 247 human transcription factors. The models were pooled from various publicly accessible data sources, such as CIS-BP, Hocomoco, hPDI, JASPAR and Jolma (2013). 103 transcription factor flexible models (TFFMs) are included. For each binding model, FABIAN constructs a Bayes classifier and reports the likelihood that a variant leads to the gain or loss of a transcription factor binding site. Because of the poor performance of several binding models in detecting experimentally verified sites, a negative or positive predictive value is reported.

::DEVELOPER

FABIAN team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

Web browser

:: DOWNLOAD

:: MORE INFORMATION

Citation

A systematic, large-scale comparison of transcription factor binding site models.
Hombach D, Schwarz JM, Robinson PN, Schuelke M, Seelow D.
BMC Genomics. 2016 May 21;17(1):388. doi: 10.1186/s12864-016-2729-8.