DISCO 1.0 – Structure Determination of Protein Homo-oligomers

DISCO 1.0

:: DESCRIPTION

DISCO is software to perform structure determination of protein homo-oligomers with cyclic symmetry.DISCO computes oligomeric protein structures using geometric constraints derived from RDCs and intermolecular distance restraints such as NOEs or disulfide bonds. When a reliable subunit structure can be calculated from intramolecular restraints, DISCO guarantees that all satisfying oligomer structures will be discovered, yet can run in minutes to hours on only a single desktop-class computer.

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::DEVELOPER

Donald Lab at Duke University

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux / MacOSX
  • Java

:: DOWNLOAD

DISCO

:: MORE INFORMATION

Citation

Jeffrey W. Martin, Anthony K. Yan, Chris Bailey-Kellogg, Pei Zhou, and Bruce R. Donald.
A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers.
Protein Science, 20(6):970-985, 2011.

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