DamMet is probabilistic model for mapping ancient methylomes using sequencing data underlying an ancient specimen. The model is implemented as a two step procedure. The first step recovers a maximum likelihood estimate (MLE) of the position specific deamination rates for methylated and unmethylated cytosine residues. The second step, making use of these deamination rates, returns a MLE of the methylation level in a user-defined genomic window. The software is multithreaded
:: MORE INFORMATION
Hanghoj K, Renaud G, Albrechtsen A, Orlando L.
DamMet: ancient methylome mapping accounting for errors, true variants, and post-mortem DNA damage.
Gigascience. 2019 Apr 1;8(4):giz025. doi: 10.1093/gigascience/giz025. PMID: 31004132; PMCID: PMC6474913.