CVTree 4.0 – Construct Prokaryotic Phylogency Tree by using Composition Vector Approach

CVTree 4.0


CVTree (Composition Vector Tree) constructs phylogeny trees without alignment, using a composition vector (CV) approach. The new method is based on whole genome of organisms and it is developed to infer the evolutionary relatedness of microbial organisms first, and also successfully used in the classifications of chloroplast and coronavirus. It circumvents the ambiguity of choosing the genes for phylogenetic reconstruction and avoids the necessity of aligning sequences of essentially different length and gene content.



CVTree team




  • Linux / Windows
  • C++ Compiler





Zuo G.
CVTree: A Parallel Alignment-free Phylogeny and Taxonomy Tool based on Composition Vectors of Genomes.
Genomics Proteomics Bioinformatics. 2021 Jun 10:S1672-0229(21)00100-5. doi: 10.1016/j.gpb.2021.03.006. Epub ahead of print. PMID: 34119695.

Zhao Xu, Bailin Hao,
CVTree update: a newly designed phylogenetic study platform using composition vectors and whole genomes“,
Nucleic Acids Res. 2009 37(Web Server issue): W174-W178.

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