CooperativeDimer
:: DESCRIPTION
CooperativeDimer is a software developed in Mathematica for the analysis of the affinities and any cooperativity in ligand binding to a dimer (or other molecule containing two equivalent binding sites). The approach requires data on the fractional populations of all three species (apo, singly and doubly bound) such as may be obtained from mass spectrometry or NMR data.
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::DEVELOPER
:: SCREENSHOTS
N/A
:: REQUIREMENTS
- Linux / Windows / MacOsX
- Mathematica
:: DOWNLOAD
:: MORE INFORMATION
Citation
Marcus J. Edwards, Mark A. Williams, Anthony Maxwell and Adam R. McKay (2011).
Mass spectrometry reveals the antibiotic simocyclinone D8 binds DNA gyrase in “bent over” conformation: evidence for positive coperativity.
Biochemistry. 2011 May 3;50(17):3432-40. Epub 2011 Apr 5.