ALoFT 1.0 – Annotation of Loss-of-Function Transcripts

ALoFT 1.0

:: DESCRIPTION

ALoFT provides extensive annotations to putative loss-of-function variants (LoF) in protein-coding genes including functional, evolutionary and network features. Further, ALoFT can predict the impact of premature stop variants and classify them as dominant disease-causing, recessive disease-causing and benign variants.

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::DEVELOPER

Gerstein Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

ALoFT

:: MORE INFORMATION

Citation:

Nat Commun. 2017 Aug 29;8(1):382. doi: 10.1038/s41467-017-00443-5.
Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes.
Balasubramanian S, Fu Y, Pawashe M, McGillivray P, Jin M, Liu J, Karczewski KJ, MacArthur DG, Gerstein M

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